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Cysteine Protease


Cysteine proteases (thiol proteases) are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad. Cysteine proteases play multi-faceted roles, virtually in every aspect of physiology and development. In humans and other animals, they are responsible for senescence and apoptosis (programmed cell death), MHC class II immune responses, prohormone processing, and extracellular matrix remodeling important to bone development. 
  • E-64 EY1852

    E-64 是一种作用于木瓜蛋白酶的选择性的不可逆的半胱氨酸蛋白酶抑制剂,其IC50为9 nM。

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  • Cathepsin Inhibitor 1 EY1627

    Cathepsin Inhibitor 1是一种组织蛋白酶(L, L2, S, K, B)的抑制剂, pIC50分别为7.9, 6.7, 6.0, 5.5, 5.2。

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  • Aloxistatin EY0471

    Aloxistatin 是一种不可逆的膜透过性cysteine protease 抑制剂。

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  • MG-101 EY0341

    MG-101是一种有效的半胱氨酸蛋白酶抑制剂, 作用于钙蛋白酶I, 钙蛋白酶II, 组织蛋白酶B, 和组织蛋白酶L, Ki值分别为190 nM , 220 nM, 150 nM, 500 pM.

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  • Calpeptin EY1839

    Calpeptin是一种有效的,细胞渗透性 calpain 抑制剂,对钙蛋白酶 I (猪红细胞),钙蛋白酶 II (猪肾脏),木瓜蛋白酶,和钙蛋白酶 I (人血小板)的ID50分别为52 nM,34 nM,138 nM,和40 nM 。

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