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DNA Methyltransferase

DNA methyltransferase (DNA MTase) family of enzymes catalyze the transfer of a methyl group to DNA. DNA methylation serves a wide variety of biological functions. All the known DNA methyltransferases use S-adenosyl methionine (SAM) as the methyl donor. Three active DNA methyltransferases have been identified in mammals. They are named DNMT1, DNMT3A, and DNMT3B. A fourth enzyme previously known as DNMT2 is not a DNA methyltransferase.
  • Decitabine EY1780

    Decitabine是一种有效的DNA甲基化抑制剂,作用于HL-60和KG1a细胞时,IC50分别为100 ng/mL和1 ng/mL。

  • Zebularine EY1710

    Zebularine(NSC309132; 4-Deoxyuridine)是DNA甲基化抑制剂,能与DNA甲基化酶共价结合,也能抑制Cytidinedeaminase酶活性,Ki值为2uM。

  • SGI-1027 EY1534

    SGI-1027是DNA甲基转移酶(DNMT)抑制剂,对DNMT1,DNMT3A和DNMT3B的IC50分别为6,8和7.5 μM。

  • RG108 EY1107

    RG108是非核苷类DNA甲基转移酶抑制剂,IC50为115 nM。

  • Azacitidine EY0611

    Azacitidine 是胞苷的核苷类似物,通过捕获DNA甲基,特异性抑制DNA methylation(DNA甲基化)。

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