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p38 MAPK

p38 MAPK are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. p38 MAPK is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress. Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light, and growth factors.
  • EO 1428 EI1086

    EO 1428是p38α 和 p38β2选择性抑制剂。

  • CMPD-1 EI0832

    CMPD-1是非ATP竞争性 p38α 抑制剂, 也是微管蛋白聚合的抑制剂。

  • CGH 2466 dihydrochloride EI0740

    CGH 2466 dihydrochloride是A1, A2B 和 A3 拮抗剂,p38 MAPK和PDE4的抑制剂。

  • AMG 548 EI0432

    AMG 548是活性的,选择性 p38α 抑制剂。

  • AL 8697 EI0411

    AL 8697是活性的,选择性 p38α 抑制剂。

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