The AXL protein is a cell surface recepto that is a member of the receptor tyrosine kinase subfamily. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6). It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. AXL may play an important role in Zika virus infection, allowing for entry of the virus into host cells. AXL receptor tyrosine kinase has been shown to interact with TENC1. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.