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Axl


The AXL protein is a cell surface recepto that is a member of the receptor tyrosine kinase subfamily. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6 (GAS6). It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. AXL may play an important role in Zika virus infection, allowing for entry of the virus into host cells. AXL receptor tyrosine kinase has been shown to interact with TENC1. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.

  • R428 EY1287

    R428是Axl抑制剂，IC50为14 nM。

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  • Cabozantinib EY1204

    Cabozantinib (XL184, BMS-907351)是一种有效的VEGFR2抑制剂，在无细胞试验中IC50为0.035 nM，也能有效抑制c-Met、 Ret、 Kit、Flt-1/3/4、Tie2和AXL，IC50分别为1.3 nM，4 nM，4.6 nM，12 nM/11.3 nM/6 nM，14.3 nM 和 7 nM。

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