DHFR
DHFR (Dihydrofolate reductase) is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. It is found in the q11→q22 region of chromosome 5. In all organisms, DHFR has a critical role in regulating the amount of tetrahydrofolate in the cell. Tetrahydrofolate and its derivatives are essential for purine and thymidylate synthesis, which are important for cell proliferation and cell growth.
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Methotrexate(WR19039; CL14377)能干扰生长迅速的细胞，如癌细胞，骨髓细胞和表皮细胞。
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Pemetrexed是一种新型抗叶酸抗代谢药物，作用于TS， DHFR和GARFT时，Ki分别为1.3 nM，7.2 nM，和65 nM。
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Pemetrexed是新型抗叶酸和抗代谢化合物，对TS，DHFR和GARFT的Ki分别为1.3 nM，7.2 nM和65 nM。
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Pyrimethamine可通过抑制二氢叶酸还原酶（DHFR）干扰四氢叶酸的合成，可作用于原生动物的感染。
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