HSP


HSPs are a family of proteins that are produced by cells in response to exposure to stressful conditions. Many members of this group perform chaperone function by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). Heat-shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins on the order of 60, 70, and 90 kilodaltons in size, respectively. The small 8-kilodalton protein ubiquitin, which marks proteins for degradation, also has features of a heat shock protein. Heat Shock Factor 1 (HSF1) is a transcription factor that is involved in the general maintenance and upregulation of Hsp70 protein expression. HSF1 inhibition by a potent RNA aptamer attenuates mitogenic (MAPK) signaling and induces cancer cell apoptosis.
  • Herbimycin A EI1293

    Herbimycin A是Src 家族激酶抑制剂。也是Hsp90 抑制剂。

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  • Gedunin EI1178

    Gedunin是Hsp90 抑制剂, 展现抗肿瘤抗疟活性。。

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  • EC 144 EI1053

    EC 144是高亲和性,活性的选择性 Hsp90 抑制剂。

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  • CCT 018159 EI0711

    CCT 018159是Hsp90 抑制剂。

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  • TRC 051384 EI2812

    TRC 051384是TRC 051384 is an inducer of heat shock protein Hsp70。

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  • Herbimycin A EI1293

    Herbimycin A是Src 家族激酶抑制剂。也是Hsp90 抑制剂。

    More
  • Gedunin EI1178

    Gedunin是Hsp90 抑制剂, 展现抗肿瘤抗疟活性。。

    More
  • EC 144 EI1053

    EC 144是高亲和性,活性的选择性 Hsp90 抑制剂。

    More
  • CCT 018159 EI0711

    CCT 018159是Hsp90 抑制剂。

    More
  • TRC 051384 EI2812

    TRC 051384是TRC 051384 is an inducer of heat shock protein Hsp70。

    More
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