SGLT
SGLT (sodium-glucose linked transporter) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption. In the kidneys, 100% of the filtered glucose in the glomerulus has to be reabsorbed along the nephron (98% in PCT, via SGLT2). If the plasma glucose concentration is too high (hyperglycemia), glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. Glucose is never secreted by a healthy nephron. The two most well known members of SGLT family are SGLT1 and SGLT2, which are members of the SLC5A gene family. In addition to SGLT1 and SGLT2, there are five other members in the human protein family SLC5A, several of which may also be sodium-glucose transporters.
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LX-4211是SGLT1/2抑制剂，是抗糖尿病剂。
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Canagliflozin是高活性hSGLT2选择性抑制剂，IC50为2.2 nM，比对hSGLT1的抑制性强413倍。
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Empagliflozin (BI 10773)是一种有效的，选择性SGLT-2抑制剂，IC50为3.1 nM，比作用于SGLT-1， 4， 5和6选择性高300倍以上。
More
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Dapagliflozin是口服活性的SGLT2抑制剂，可作用于2型糖尿病。
More
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LX-4211是SGLT1/2抑制剂，是抗糖尿病剂。
More
-
Canagliflozin是高活性hSGLT2选择性抑制剂，IC50为2.2 nM，比对hSGLT1的抑制性强413倍。
More
-
Empagliflozin (BI 10773)是一种有效的，选择性SGLT-2抑制剂，IC50为3.1 nM，比作用于SGLT-1， 4， 5和6选择性高300倍以上。
More
-
Dapagliflozin是口服活性的SGLT2抑制剂，可作用于2型糖尿病。
More
-
LX-4211是SGLT1/2抑制剂，是抗糖尿病剂。
More
-
Canagliflozin是高活性hSGLT2选择性抑制剂，IC50为2.2 nM，比对hSGLT1的抑制性强413倍。
More
-
Empagliflozin (BI 10773)是一种有效的，选择性SGLT-2抑制剂，IC50为3.1 nM，比作用于SGLT-1， 4， 5和6选择性高300倍以上。
More
-
Dapagliflozin是口服活性的SGLT2抑制剂，可作用于2型糖尿病。
More
