NRTIs
Reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. It is mainly associated with retroviruses. RT inhibitors are widely used as antiretroviral drugs. RT activities are also associated with the replication of chromosome ends (telomerase) and some mobile genetic elements (retrotransposons).
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Zidovudine是核苷类似物逆转录酶抑制剂(NRTI),可作用于HIV/AIDS感染。
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Lamivudine (拉米夫定) 为核苷类似物,是逆转录酶抑制剂,IC50为2.7 mM。
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Zalcitabine是一种核苷类HIV逆转录酶抑制剂(NARTI)。
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Stavudine是核苷类似物,能抑制HIV逆转录酶。
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