Casein Kinase(CK1/CK2)
Casein kinase activity was found to be present in most cell types and to be associated with multiple enzymes. The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription. The type 1 casein kinase family of related gene products are now given designations such as "casein kinase 1 alpha" and "casein kinase 1 epsilon". The Casein kinase 2 is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes. Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation.
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CKI 7 dihydrochloride是CK1 抑制剂。
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(R)-DRF053 dihydrochloride是Dual CK1/cdk 抑制剂。
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TMCB是双效的激酶抑制剂， 抑制CK2，ERK8。
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PF 670462是活性的，选择性 CK1ε and CK1δ 抑制剂。
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CX-4945 (Silmitasertib), a selective, potent and orally bioavailable inhibitor of potent casein kinase II (CK2), is the first small molecule inhibitor of CK2 to progress to human clinical trials. CX-4945 (Silmitasertib)是高活性ATP竞争性CK2抑制剂，对重组型人CK2α的Ki和IC50分别为0.38和1 nM。
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CKI 7 dihydrochloride是CK1 抑制剂。
More
-
(R)-DRF053 dihydrochloride是Dual CK1/cdk 抑制剂。
More
-
TMCB是双效的激酶抑制剂， 抑制CK2，ERK8。
More
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PF 670462是活性的，选择性 CK1ε and CK1δ 抑制剂。
More
-
CX-4945 (Silmitasertib), a selective, potent and orally bioavailable inhibitor of potent casein kinase II (CK2), is the first small molecule inhibitor of CK2 to progress to human clinical trials. CX-4945 (Silmitasertib)是高活性ATP竞争性CK2抑制剂，对重组型人CK2α的Ki和IC50分别为0.38和1 nM。
More
