Integrin
Integrins are transmembrane receptors that are the bridges for cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrins trigger chemical pathways to the interior (signal transduction). This results in a response (activation of transcription) like the regulation of the cell cycle, cell shape, and/or motility; or new receptors being added to the cell membrane. This allows rapid and flexible responses to events at the cell surface, for example to signal platelets to initiate an interaction with coagulation factors.
Integrins are obligate heterodimers, meaning that they have two different chains: the α (alpha) and β (beta) subunits.
Integrins work alongside other receptors such as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans to mediate cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen, and laminin.
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GR 144053 trihydrochloride是Glycoprotein IIb/IIIa (integrin αIIbβ3) 受体 拮抗剂。 抗血栓活性。
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BTT 3033是整合蛋白 α2β1的选择性抑制剂。
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BIO 5192是整合蛋白 α4β1的高活性的选择性抑制剂。
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Cilengitide是一种有效的integrin（整合素）抑制剂，作用于αvβ3受体和αvβ5受体，IC50分别为4.1 nM和79 nM，比作用于gpIIbIIIa选择性高10倍左右。
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RGD (Arg-Gly-Asp) Peptides是一种细胞粘附序列，可以模仿细胞粘附蛋白并与整合素结合。
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GR 144053 trihydrochloride是Glycoprotein IIb/IIIa (integrin αIIbβ3) 受体 拮抗剂。 抗血栓活性。
More
-
BTT 3033是整合蛋白 α2β1的选择性抑制剂。
More
-
BIO 5192是整合蛋白 α4β1的高活性的选择性抑制剂。
More
-
Cilengitide是一种有效的integrin（整合素）抑制剂，作用于αvβ3受体和αvβ5受体，IC50分别为4.1 nM和79 nM，比作用于gpIIbIIIa选择性高10倍左右。
More
-
RGD (Arg-Gly-Asp) Peptides是一种细胞粘附序列，可以模仿细胞粘附蛋白并与整合素结合。
More
