Gamma-secretase
Gamma secretase (γ-secretase) is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch,ErbB4,E-cadherin, N-cadherin,ephrin-B2,or CD44. The gamma secretase complex consists of four individual proteins: PSEN1 (presenilin-1),nicastrin, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer 2).
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PF-3084014 is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.
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Flurizan是γ-secretase 抑制剂， 在体外降低 Aβ42的水平。
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Compound W是γ-secretase 抑制剂。
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Begacestat是γ-secretase 抑制剂， lowers Aβ40，Aβ42 levels。
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TC-E 5006是γ-secretase调节剂，降低Aβ42的水平。
More
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PF-3084014 is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.
More
-
Flurizan是γ-secretase 抑制剂， 在体外降低 Aβ42的水平。
More
-
Compound W是γ-secretase 抑制剂。
More
-
Begacestat是γ-secretase 抑制剂， lowers Aβ40，Aβ42 levels。
More
-
TC-E 5006是γ-secretase调节剂，降低Aβ42的水平。
More
-
PF-3084014 is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.
More
-
Flurizan是γ-secretase 抑制剂， 在体外降低 Aβ42的水平。
More
-
Compound W是γ-secretase 抑制剂。
More
-
Begacestat是γ-secretase 抑制剂， lowers Aβ40，Aβ42 levels。
More
-
TC-E 5006是γ-secretase调节剂，降低Aβ42的水平。
More
