EAATs(Glutamate transporters)
EAATs (Glutamate transporters, Excitatory amino-acid transporters,SLC1, GLT-1), being the most abundant subtype of glutamate transporter in the CNS, is a protein thatplays a key role in regulation of glutamate neurotransmission. and are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1) found widely distributed throughout the brain. There are five EAAT subtypes, each with a specific primary distribution; EAAT1 (cerebellar glia), EAAT2 (forebrain glia), EAAT3 (cortical neurons), EAAT4 (cerebellar Purkinje neurons) and EAAT5 (retina).
-
D-I03 is a selective inhibitor of RAD52 with a Kd value of 25.8 µM.
D-I03 inhibits ssDNA annealing via RAD52 and D-loop formation, with IC50 values of 5 µM and 8 µM, respectively.
More
-
SCR7 pyrazine is an inhibitor of DNA ligase IV that blocks non-homologous end joining (NHEJ) in a ligase IV‑dependent manner. SCR7 pyrazine enhances the efficiency of Cas9‑mediated homology‑directed repair (HDR). SCR7 pyrazine induces apoptosis and exhibits anticancer activity.
More
-
More
-
Procarbazine HCl是一种抗肿瘤药。可作用于霍奇金氏淋巴瘤和一些脑癌。
More
-
Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.
Phase 2.
More
