B02 是一种人源 RAD51 小分子抑制剂,IC50 为 27.4 μM,对大肠杆菌中的同源蛋白 RecA 无抑制作用(IC50>250 μM)。
MoreTribromoethyl alcohol (2,2,2-Tribromoethanol) 被用来作用于实验动物
MoreRalometostat (TNG908) is a potent, selective, and brain-penetrant PRMT5 inhibitor with an IC50 of 4 μM, exerting its effect through an MTA synergistic mechanism. It also demonstrates antitumor activity in xenograft models.
MoreMRTX1719 is a potent and selective inhibitor of the protein arginine methyltransferase 5·methylthioadenosine phosphorylase complex (PRMT5·MTA), which serves as a potential selective therapeutic target for tumor intervention.
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