CSF-1R


CSF1R (Colony stimulating factor 1 receptor,M-CSFR,CD115) is a receptor for a cytokine called colony stimulating factor 1. It controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSF1R through a process of oligomerization and trans-phosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. 
  • GW2580 EY1286

    GW2580是c-FMS激酶口服活性抑制剂,体外实验60nM浓度能完全抑制c-FMS酶活性,对其他26种激酶没有抑制作用。

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  • BLZ945 EY1142

    BLZ945是CSF1R高效选择性抑制剂,IC50值为1 nM,对其他激酶基本无作用。

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  • Pexidartinib EY0507

    Pexidartinib是受体酪氨酸激酶Fms,Kit和Flt3小分子抑制剂,临床2期。

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