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Prazosin HCl

盐酸哌唑嗪,cp-12299-1,Furazosin,Minipress,Hypovase HCl,

Prazosin hydrochloride是α肾上腺素阻断剂，可作用于高血压、焦虑和恐慌症等。

目录号
EY0986
EY0986
EY0986
纯度
99.66%
99.66%
99.66%
规格
100 mg
200 mg
500 mg
原价
460_
830_
1700
售价
460_
830_
1700
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Prazosin HCl is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Baum O, et al. Am J Physiol Heart Circ Physiol,?004, 287(5), H2300-H2308.

    分子式
    C19H22ClN5O4    		 分子量
    419.86    		 CAS号
    19237-84-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    10 mM    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01178138 Continuous Methamphetamine Abuse Drug: Prazosin University of Arkansas|National Institute on Drug Abuse (NIDA) Phase 2 2009-12-01 2016-11-09
    NCT00753064 Scorpion Envenomation Drug: Antiscorpion venom serum(AScVS).|Drug: T.Prazosin|Drug: AScVS + Prazosin Haffkine Bio-Pharmaceutical Corporation Ltd. Phase 3 2006-09-01 2008-09-15
    NCT00744055 Alcohol Dependence|Stress Disorders, Post-Traumatic Drug: Prazosin|Drug: Placebo Yale University Phase 3 2009-01-01 2016-03-18
    NCT01621165 Bipolar, Mania|Bipolar, Mixed State Drug: Addition of prazosin to usual care (add-on study)|Drug: Placebo Mclean Hospital 2009-03-01 2012-06-15
    NCT01518972 Alcohol Abuse|Posttraumatic Stress Disorder Drug: Prazosin|Drug: Placebo medication Seattle Institute for Biomedical and Clinical Research|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|VA Puget Sound Health Care System Phase 2 2009-09-01 2012-08-13
    NCT01126099 Alzheimer's Disease Drug: Prazosin|Drug: Placebo Seattle Institute for Biomedical and Clinical Research|National Institute on Aging (NIA)|VA Puget Sound Health Care System 2010-03-01 2015-05-19
    NCT02193256 Cigarette Smoking|Alcohol Use Disorders Drug: Varenicline|Drug: Prazosin|Drug: Placebo Yale University|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Early Phase 1 2014-07-01 2016-05-11
    NCT00183430 Post-Traumatic Stress Disorder|Sleep Initiation and Maintenance Disorders Drug: Prazosin|Drug: Placebo|Behavioral: Psychotherapy Seattle Institute for Biomedical and Clinical Research|National Institute of Mental Health (NIMH) 2003-10-01 2012-11-26
    NCT02965027 Post-Traumatic Headache Drug: Prazosin|Drug: Placebos Seattle Institute for Biomedical and Clinical Research|VA Puget Sound Health Care System|Madigan Army Medical Center Phase 4 2016-11-01 2016-11-18
    NCT03045016 Acute Stress Disorder Drug: Prazosin, ALPRESS LP 2,5 et 5 mg Hospices Civils de Lyon Phase 2 2017-02-01 2017-02-06
    NCT02431936 Hypertension|Stress, Psychological|Blood Pressure Drug: Prazosin|Drug: Placebo Augusta University|The University of Texas at Arlington Phase 2 2015-04-01 2016-10-19
    NCT02226367 Alcohol Use Disorders|Stress Disorders, Posttraumatic|Combat Disorders Drug: prazosin hydrochloride|Drug: placebo Seattle Institute for Biomedical and Clinical Research|United States Department of Defense|VA Puget Sound Health Care System 2015-01-01 2016-10-17
    NCT00990106 Stress Disorders, Post-Traumatic|Combat Disorders|Sleep Disorders Drug: prazosin hydrochloride|Drug: placebo Seattle Institute for Biomedical and Clinical Research|United States Department of Defense|VA Puget Sound Health Care System|National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2009-09-01 2014-08-28
    NCT00762710 Alcoholism Drug: Prazosin medication|Drug: Placebo medication Seattle Institute for Biomedical and Clinical Research|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|VA Puget Sound Health Care System|University of Washington Phase 2 2009-01-01 2013-08-05
    NCT01999530 Healthy Drug: Prazosin Hydrochloride Centre for Addiction and Mental Health|Ontario Lung Association|Pfizer Phase 1 2013-11-01 2016-12-21
    NCT02266329 Posttraumatic Headache|Combat Disorders|Post Concussion Syndrome|Headache|Mild Traumatic Brain Injury|Posttraumatic Migraine Drug: prazosin hydrochloride|Drug: placebo VA Office of Research and Development 2016-01-01 2017-01-10
    NCT00890643 Posttraumatic Stress Disorder Drug: prazosin hydrochloride|Drug: placebo VA Office of Research and Development 2009-12-01 2013-09-20
    NCT00175682 Autonomic Dysreflexia Drug: Prazosin HCL University of British Columbia 2004-12-01 2017-03-01
    NCT00532493 PTSD|Sleep Disorders Drug: prazosin|Other: placebo VA Office of Research and Development Phase 3 2010-01-01 2016-12-16
    NCT02322047 Alcohol Use Disorder|PTSD Drug: Prazosin|Drug: Naltrexone|Drug: Placebo|Drug: Placebo Seattle Institute for Biomedical and Clinical Research|United States Department of Defense|VA Puget Sound Health Care System Phase 2 2014-11-01 2016-12-23
    NCT01642433 Nicotine Dependence Drug: Placebo|Drug: Prazosin Centre for Addiction and Mental Health|Ontario Lung Association Phase 2 2012-07-01 2015-07-15
    NCT00202449 Stress Disorders, Post-Traumatic|Sleep Disorders Drug: prazosin|Drug: paroxetine|Drug: Placebo Seattle Institute for Biomedical and Clinical Research|United States Department of Defense|VA Puget Sound Health Care System 2004-07-01 2012-06-11
    NCT00240227 Alcoholism|Cocaine Dependence Drug: Prazosin|Drug: placebo VA Office of Research and Development 2004-04-01 2016-03-11
    NCT00108420 Stress Disorder, Post-Traumatic Drug: Prazosin VA Office of Research and Development Phase 4 2003-10-01 2009-01-20

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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