CaSR
CaSR(The calcium-sensing receptor) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. It is primarily expressed in the parathyroid gland and the renal tubules of the kidney. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). In the kidney it has an inhibitory effect on the reabsorbtion of calcium, potassium, sodium, and water depending on which segment of the tubule is being activated.
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Gadolinium chloride是Stretch-activated calcium的通道阻断剂， calcium-sensing的受体激动剂。
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Strontium chloride是Calcium sensing receptor (CaSR)的激动剂。
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R 568 hydrochloride是人 calcium-sensing 受体的阳性变构的调节剂（positive allosteric modulator）。
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NPS 2143 hydrochloride是calcium-sensing受体选择性拮抗剂， 口服有效的催化剂。
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NPS-2143是一种新型有效的，选择性的Ca(2+)受体拮抗剂，IC50为43 nM。
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