Propranolol HCl

盐酸普萘洛尔,AY-64043,ICI-45520,NCS-91523,Inderal hydrochloride,ICI45520,ICI 45520,NCS91523

Propranolol HCl

目录号
EY0921
EY0921
EY0921
纯度
99.42%
99.42%
99.42%
规格
50 mg
100 mg
500 mg
原价
300
400
600
售价
300
400
600
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Fujita, K., et al. 1996. FEBS Lett. 395: 293-298. PMID: 8898114
    [2] Glennon, R.A., et al. 1996. Mol. Pharmacol. 49: 198-206. PMID: 8569707
    [3] Y Karrout et. Al. Journal of Controlled Release, 197, 121-130 (2015).

    分子式
    C16H22ClNO2
    分子量
    295.8
    CAS号
    318-98-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    4 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02268357 Dental Anxiety Drug: Propranolol Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Phase 2|Phase 3 2014-10-01 2016-08-10
    NCT02012777 Sickle Cell Disease Drug: propranolol University of Miami|Duke University Phase 1 2010-06-01 2016-08-24
    NCT00864747 Healthy Drug: Propranolol Hydrochloride Extended Release Capsules 160 mg|Drug: INDERAL LA 160 mg Capsules, single dose Actavis Inc. Phase 1 2005-05-01 2010-08-13
    NCT02595996 Primary Lymphedema Drug: Propranolol Columbia University 2015-12-01 2015-11-02
    NCT02414451 Autism Drug: Propranolol|Drug: Placebo University of Missouri-Columbia 2016-09-01 2016-10-03
    NCT02962947 Melanoma Drug: Propranolol|Drug: Placebo Azienda Sanitaria di Firenze Phase 2|Phase 3 2017-06-01 2016-11-09
    NCT01079715 Retinopathy of Prematurity Drug: Propranolol Azienda Ospedaliero, Universitaria Meyer|Ospedale Maggiore Policlinico Mangiagalli e Regina Elena Phase 2|Phase 3 2010-01-01 2012-11-24
    NCT00597389 Posttraumatic Stress Disorders Drug: Inderol (propranolol) Kent State University|Akron Children's Hospital|Ohio Board of Regents 2004-02-01 2008-01-17
    NCT02014454 Retinopathy of Prematurity Drug: Propranolol eye drops Azienda Ospedaliero, Universitaria Meyer Phase 2 2013-11-01 2015-07-06
    NCT02596867 Breast Cancer Drug: propanolol Texas Tech University Health Sciences Center, El Paso Phase 2 2015-09-01 2016-11-07
    NCT01238471 Retinopathy of Prematurity Drug: propranolol|Drug: sucrose 5% Rambam Health Care Campus|Hadassah Medical Organization|Laniado Hospital|Nazareth Hospital Phase 1|Phase 2 2010-05-01 2014-06-12
    NCT02111369 Essential Vocal Tremor|Essential Voice Tremor|Essential Tremor|Voice Tremor|Vocal Tremor Drug: Propranolol|Procedure: Botulinum Toxin Emory University Phase 4 2014-05-01 2016-03-25
    NCT02428205 Autism Drug: Propranolol|Drug: Placebo University of Missouri-Columbia|Autism Science Foundation 2015-04-01 2016-10-03
    NCT03029845 Fibromyalgia Pain Drug: Propranolol 1|Drug: Propranolol 2|Drug: Placebo University of Utah Phase 1 2017-01-01 2017-01-20
    NCT02437383 Temporomandibular Disorders Drug: Propranolol ER|Drug: Placebo University of North Carolina, Chapel Hill|University of Florida|Rho, Inc.|National Institutes of Health (NIH)|National Institute of Dental and Craniofacial Research (NIDCR)|State University of New York at Buffalo Phase 2 2015-08-01 2016-12-01
    NCT02504944 Retinopathy of Prematurity Drug: Propranolol 0.2% eye drops Azienda Ospedaliero, Universitaria Meyer Phase 2 2015-07-01 2016-07-12
    NCT00315913 Dysfunctional Labor Drug: Propranolol|Other: IV Placebo University of California, Irvine Phase 2 2004-01-01 2014-12-05
    NCT01069159 Traumatic Memory|Posttraumatic Stress Disorder Drug: Propranolol Hydrochloride|Drug: Placebo Mela, Mansfield, M.D. 2010-02-01 2011-06-19
    NCT00865215 Healthy Drug: Propranolol Hydrochloride Extended Release Capsules 160 mg|Drug: INDERAL庐 LA 160 mg Capsules, single dose Actavis Inc. Phase 1 2005-04-01 2010-08-13
    NCT01957449 Burn Drug: Propranolol|Drug: Placebo The University of Texas Medical Branch, Galveston|Shriners Hospitals for Children Phase 2|Phase 3 2013-12-01 2016-03-09

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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