Propranolol HCl
Propranolol HCl is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Fujita, K., et al. 1996. FEBS Lett. 395: 293-298. PMID: 8898114
[2] Glennon, R.A., et al. 1996. Mol. Pharmacol. 49: 198-206. PMID: 8569707
[3] Y Karrout et. Al. Journal of Controlled Release, 197, 121-130 (2015).
分子式 C16H22ClNO2 |
分子量 295.8 |
CAS号 318-98-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water 4 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02268357 | Dental Anxiety | Drug: Propranolol | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 2|Phase 3 | 2014-10-01 | 2016-08-10 |
NCT02012777 | Sickle Cell Disease | Drug: propranolol | University of Miami|Duke University | Phase 1 | 2010-06-01 | 2016-08-24 |
NCT00864747 | Healthy | Drug: Propranolol Hydrochloride Extended Release Capsules 160 mg|Drug: INDERAL LA 160 mg Capsules, single dose | Actavis Inc. | Phase 1 | 2005-05-01 | 2010-08-13 |
NCT02595996 | Primary Lymphedema | Drug: Propranolol | Columbia University | 2015-12-01 | 2015-11-02 | |
NCT02414451 | Autism | Drug: Propranolol|Drug: Placebo | University of Missouri-Columbia | 2016-09-01 | 2016-10-03 | |
NCT02962947 | Melanoma | Drug: Propranolol|Drug: Placebo | Azienda Sanitaria di Firenze | Phase 2|Phase 3 | 2017-06-01 | 2016-11-09 |
NCT01079715 | Retinopathy of Prematurity | Drug: Propranolol | Azienda Ospedaliero, Universitaria Meyer|Ospedale Maggiore Policlinico Mangiagalli e Regina Elena | Phase 2|Phase 3 | 2010-01-01 | 2012-11-24 |
NCT00597389 | Posttraumatic Stress Disorders | Drug: Inderol (propranolol) | Kent State University|Akron Children's Hospital|Ohio Board of Regents | 2004-02-01 | 2008-01-17 | |
NCT02014454 | Retinopathy of Prematurity | Drug: Propranolol eye drops | Azienda Ospedaliero, Universitaria Meyer | Phase 2 | 2013-11-01 | 2015-07-06 |
NCT02596867 | Breast Cancer | Drug: propanolol | Texas Tech University Health Sciences Center, El Paso | Phase 2 | 2015-09-01 | 2016-11-07 |
NCT01238471 | Retinopathy of Prematurity | Drug: propranolol|Drug: sucrose 5% | Rambam Health Care Campus|Hadassah Medical Organization|Laniado Hospital|Nazareth Hospital | Phase 1|Phase 2 | 2010-05-01 | 2014-06-12 |
NCT02111369 | Essential Vocal Tremor|Essential Voice Tremor|Essential Tremor|Voice Tremor|Vocal Tremor | Drug: Propranolol|Procedure: Botulinum Toxin | Emory University | Phase 4 | 2014-05-01 | 2016-03-25 |
NCT02428205 | Autism | Drug: Propranolol|Drug: Placebo | University of Missouri-Columbia|Autism Science Foundation | 2015-04-01 | 2016-10-03 | |
NCT03029845 | Fibromyalgia Pain | Drug: Propranolol 1|Drug: Propranolol 2|Drug: Placebo | University of Utah | Phase 1 | 2017-01-01 | 2017-01-20 |
NCT02437383 | Temporomandibular Disorders | Drug: Propranolol ER|Drug: Placebo | University of North Carolina, Chapel Hill|University of Florida|Rho, Inc.|National Institutes of Health (NIH)|National Institute of Dental and Craniofacial Research (NIDCR)|State University of New York at Buffalo | Phase 2 | 2015-08-01 | 2016-12-01 |
NCT02504944 | Retinopathy of Prematurity | Drug: Propranolol 0.2% eye drops | Azienda Ospedaliero, Universitaria Meyer | Phase 2 | 2015-07-01 | 2016-07-12 |
NCT00315913 | Dysfunctional Labor | Drug: Propranolol|Other: IV Placebo | University of California, Irvine | Phase 2 | 2004-01-01 | 2014-12-05 |
NCT01069159 | Traumatic Memory|Posttraumatic Stress Disorder | Drug: Propranolol Hydrochloride|Drug: Placebo | Mela, Mansfield, M.D. | 2010-02-01 | 2011-06-19 | |
NCT00865215 | Healthy | Drug: Propranolol Hydrochloride Extended Release Capsules 160 mg|Drug: INDERAL庐 LA 160 mg Capsules, single dose | Actavis Inc. | Phase 1 | 2005-04-01 | 2010-08-13 |
NCT01957449 | Burn | Drug: Propranolol|Drug: Placebo | The University of Texas Medical Branch, Galveston|Shriners Hospitals for Children | Phase 2|Phase 3 | 2013-12-01 | 2016-03-09 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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