Ros1
ROS1 is a receptor tyrosine kinase with structural similarity to the anaplastic lymphoma kinase (ALK) protein; it is encoded by the c-ros oncogen. as gene rearrangement events involving ROS1 have been described in lung and other cancers, and since such tumors have been found to be remarkably responsive to small molecule tyrosine kinase inhibitors, interest in identifying ROS1 rearrangements as a therapeutic target in cancer has been increasing. This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
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Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants.
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Hydroquinone is an inhibitor and antioxidant, also is an intermediate in the synthesis of dyes, motor fuels, and oils.
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Sodium nitrite is a myeloperoxidase inhibitor with IC50 of 1.3 μM.
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Tiopronin is a US Food and Drug Administration (FDA)-approved drug for the treatment of cystinuria by controlling the rate of cystine precipitation and excretion.
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