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mAChR


MAChRs (Muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system. Muscarinic receptors were named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpine and scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists.

  • Trospium chloride EY2850

    Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist.

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  • Flavoxate HCl EY2797

    Flavoxate Hydrochloride is a calcium channel protein inhibitor and a muscarinic acetylcholine receptor antagonist with IC50 of 12.2 μM.

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  • Glycopyrrolate EY2737

    Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic.

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  • Trihexyphenidyl hydrochloride EY2656

    Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class. Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor.

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  • Diphenidol HCl EY2590

    Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.

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  • Trospium chloride EY2850

    Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist.

    More

  • Flavoxate HCl EY2797

    Flavoxate Hydrochloride is a calcium channel protein inhibitor and a muscarinic acetylcholine receptor antagonist with IC50 of 12.2 μM.

    More

  • Glycopyrrolate EY2737

    Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic.

    More

  • Trihexyphenidyl hydrochloride EY2656

    Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class. Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor.

    More

  • Diphenidol HCl EY2590

    Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.

    More
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