Home > 暂无记录 Signal Pathway > GPCR & G Protein

GPCR & G Protein


G protein–coupled receptors (GPCRs) which are also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors, that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.

G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein–coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs.


  • MPTP hydrochloride EI1862

    MPTP hydrochloride 是可透过血脑屏障的多巴胺 (dopamine) 神经毒素,MPTP hydrochloride 可用于诱导帕金森综合症模型。MPTP hydrochloride 是 MPP+ 的前体,可以诱导凋亡 (apoptosis)。

    More
  • HLI 373 EI1300

    HLI 373是Hdm2 抑制剂,激活p53-dependent transcription。

    More
  • HA 1100 hydrochloride EI1279

    HA 1100 hydrochloride是细胞膜通透性的选择性 Rho-kinase (ROCK) 抑制剂。

    More
  • H 1152 dihydrochloride EI1274

    H 1152 dihydrochloride是选择性 Rho-kinase (ROCK) 抑制剂。

    More
  • GSK 269962 EI1243

    GSK 269962是活性选择性 ROCK 抑制剂。

    More
  • Current page1, Total Pages7, Total Record33 First Prev 12345 Next Last Goto