Home > Signal Pathway > Endocrinology & Hormones > 5-alpha Reductase

5-alpha Reductase


5-alpha Reductase are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism. There are three isoenzymes of 5α-reductase, which vary in different tissues with age.The mechanism of 5α reductase inhibition is complex, but involves the binding of NADPH to the enzyme followed by the substrate. 5α-reductase inhibitor drugs are used in benign prostatic hyperplasia, prostate cancer, pattern hair loss (androgenetic alopecia), and hormone replacement therapy for transgender women.
Inhibition of the enzyme can be classified into two categories: steroidal, which are irreversible, and nonsteroidal. 

  • Finasteride EY0545

    Finasteride是口服活性的睾酮5α-还原酶抑制剂，Ki为10 nM。

    More

  • Dutasteride EY1006

    Dutasteride是5α还原酶同工酶抑制剂，还可能因其结构域DHT相似对雄激素受体（AR）产生脱靶效应。

    More

  • Finasteride EY0545

    Finasteride是口服活性的睾酮5α-还原酶抑制剂，Ki为10 nM。

    More

  • Dutasteride EY1006

    Dutasteride是5α还原酶同工酶抑制剂，还可能因其结构域DHT相似对雄激素受体（AR）产生脱靶效应。

    More
    • Current page1, Total Pages1, Total Record2 First Prev 1 Next Last Goto
More