Home > Signal Pathway > Apoptosis > Thymidylate Synthase

Thymidylate Synthase

Thymidylate synthetase is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage.
  • Pemetrexed EY1421

    Pemetrexed是一种新型抗叶酸抗代谢药物,作用于TS, DHFR和GARFT时,Ki分别为1.3 nM,7.2 nM,和65 nM。

  • Fluorouracil EY0464

    Fluorouracil (5-Fluoracil, 5-FU)是DNA/RNA合成抑制剂,通过抑制胸苷酸合成酶(TS)而干扰核苷酸合成。

  • Current page1, Total Pages1, Total Record2 First Prev 1 Next Last Goto