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IDO


IDO (Indoleamine-pyrrole 2,3-dioxygenase) is a heme-containing enzyme that in humans is encoded by the IDO1 gene. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine using the superoxide anion as an oxygen donor. IDO is the first and rate-limiting enzyme of tryptophan catabolism through kynurenine pathway, thus causing depletion of tryptophan which can cause halted growth of microbes as well as T cells. PGE2 is able to elevate the expression of IDO in CD11C(+) dendritic cells and promotes the development of functional Treg cells.

  • NLG919 EY1350

    NLG919是一种新型有效的indoleamine-2，3-dioxygenase (IDO)（吲哚胺-2，3-双加氧酶）抑制剂，EC50为75 nM。

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  • Indoximod EY1295

    Indoximod是一种IDO抑制剂, 并逆转IDO介导的免疫抑制。

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