IDO (Indoleamine-pyrrole 2,3-dioxygenase) is a heme-containing enzyme that in humans is encoded by the IDO1 gene. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine using the superoxide anion as an oxygen donor. IDO is the first and rate-limiting enzyme of tryptophan catabolism through kynurenine pathway, thus causing depletion of tryptophan which can cause halted growth of microbes as well as T cells. PGE2 is able to elevate the expression of IDO in CD11C(+) dendritic cells and promotes the development of functional Treg cells.
  • NLG919 EY1350

    NLG919是一种新型有效的indoleamine-2,3-dioxygenase (IDO)(吲哚胺-2,3-双加氧酶)抑制剂,EC50为75 nM。

  • Indoximod EY1295

    Indoximod是一种IDO抑制剂, 并逆转IDO介导的免疫抑制。

  • Current page1, Total Pages1, Total Record2 First Prev 1 Next Last Goto