Bcr-Abl


The Philadelphia chromosome or Philadelphia translocation is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myelogenous leukemia (CML) cells). This chromosome is defective and unusually short because of reciprocal translocation of genetic material between chromosome 9 and chromosome 22, and contains a fusion gene called BCR-ABL1.
  • Radotinib EY2759

    Radotinib(IY-5511) is a novel and selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM for wild-type BCR-ABL1 kinase.

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  • GNF 2 EI1206

    GNF 2是Bcr-Abl酪氨酸激酶的选择性变构抑制剂(allosteric inhibitor)。

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  • Adaphostin EI0389

    Adaphostin是p210bcr/abl 激酶抑制剂。

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  • Imatinib Mesylate EY0363

    Imatinib Mesylate (STI571)是Imatinib的甲磺酸盐,具有较好的口服生物利用度,是一种多靶点的抑制剂,同时作用于v-Abl, c-Kit和PDGFR,IC50分别为0.6 μM, 0.1 μM 和0.1 μM。

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  • Imatinib EY0537

    Imatinib (STI571)是一种多靶点酪氨酸激酶抑制剂,作用于v- v-Abl, c-Kit和PDGFR 时,IC50分别为0.6, 0.1和0.1 μM。

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