TRP Channel
TRP channels (Transient receptor potential channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC,TRPV,TRPM,TRPN, and TRPA. In group 2, there are TRPP ,and TRPML. Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRPs have been seen to have complex multidimensional roles in sensory signaling. Many TRPs function as intracellular calcium release channels.
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Lomustine inhibits cancer cells by damaging the DNA and stops cells from dividing.
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HMM (Hexamethylmelamine,altretamine) is a synthetic, cytotoxic, antineoplastic, s-triazine derivative that can be taken orally. It is an anti-neoplastic agent. HMM has been used to treat recurrent ovarian cancer for many years and it is well tolerated
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HC 067047是活性的，选择性 TRPV4 拮抗剂。
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GSK 2193874是活性选择性 TRPV4 拮抗剂， 口服有效。
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GR 135531是高亲和性 melatonin MT3 配体。
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