Wnt/beta-catenin
The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals into a cell through cell surface receptors. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by binding a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine).
Catenin beta-1 also known as β-catenin is a protein that in humans is encoded by the CTNNB1 gene.
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. Beta-catenin is widely expressed in many tissues.Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer.
Wnt signaling and the elevated level of beta-catenin in certain cell types is the maintenance of pluripotency.
-
Cardionogen 1是Wnt/β-catenin signaling的抑制剂。
More
-
WAY 316606 hydrochloride是WAY 316606 hydrochloride is a secreted Frizzled-related protein-1 (sFRP-1) inhibitor and prevents sFRP-1 from interacting with Wnt。
More
-
QS 11是ARFGAP1 抑制剂，对 Wnt/β-catenin信号通路有调节作用。。
More
-
PNU 74654是能和β-catenin相互结合， 抑制 Wnt 信号通路。
More
-
JW 67是Wnt 通路抑制剂，诱导active β-catenin的降解。
More
-
Cardionogen 1是Wnt/β-catenin signaling的抑制剂。
More
-
WAY 316606 hydrochloride是WAY 316606 hydrochloride is a secreted Frizzled-related protein-1 (sFRP-1) inhibitor and prevents sFRP-1 from interacting with Wnt。
More
-
QS 11是ARFGAP1 抑制剂，对 Wnt/β-catenin信号通路有调节作用。。
More
-
PNU 74654是能和β-catenin相互结合， 抑制 Wnt 信号通路。
More
-
JW 67是Wnt 通路抑制剂，诱导active β-catenin的降解。
More
