MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a protein that in humans is encoded by the MALT1 gene. MALT1 is part of the paracaspase family and shows proteolytic activity. Since many of the substrates are involved in regulation of inflammatory responses, the protease activity of MALT1 has emerged as an interesting therapeutic target. Currently known protease substrates are:TNFAIP3 (A20),BCL10,CYLD,RELB,regnase-1 (MCPIP1),Roquin-1 and -2,MALT1 auto-proteolysis,HOIL1. Specifically by the oncogenic IAP2-MALT1 fusion: NIK,LIMA1.