Dehydrogenase
Dehydrogenase is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by a reduction reaction that removes one or more hydrogens from a substrate to an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN.
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Vidofludimus是免疫抑制剂，能抑制DHODH，在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。
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CPI-613是Lipoate类似物，抑制线粒体酶pyruvate dehydrogenase (PDH)（丙酮酸脱氢酶）和α-ketoglutarate dehydrogenase（α-酮戊二酸脱氢酶），干扰肿瘤细胞线粒体代谢。
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Mycophenolic acid是一种免疫抑制剂，用于预防器官移植排斥。
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AGI-5198是第一个高效的，是剂量依赖的R132H-IDH1抑制剂选择性的IDH1 R132H/R132C突变型抑制剂，IC50为0.07 μM/0.16 μM。
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AGI-6780, a heterocyclic urea sulfonamide molecule, potently and selectively inhibits the tumor-associated IDH2 R140Q mutant. AGI-6780 是一种强效的选择性 IDH2 R140Q mutant抑制剂，其IC50为 23 nM。
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