PARP


PARP (Poly (ADP-ribose) polymerase) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. The PARP family comprises 17 members. They have all very different structures and functions in the cell. PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2) have a confirmed PARP activity. Others include PARP3, PARP6, TIPARP (or "PARP7"), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. PARP is found in the cell’s nucleus. The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair. PARP activation is an immediate cellular response to metabolic, chemical, or radiation-induced DNA SSB damage. 
  • Coumarin EY2540

    Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

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  • EB 47 EI1050

    EB 47是活性的 PARP-1 抑制剂。

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  • DR 2313 EI1037

    DR 2313是PARP-1,PARP-2 抑制剂。

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  • BYK 49187 EI0657

    BYK 49187是PARP-1,PARP-2 抑制剂。

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  • 4-HQN EI0280

    4-HQN是PARP 抑制剂。

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  • Coumarin EY2540

    Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.

    More
  • EB 47 EI1050

    EB 47是活性的 PARP-1 抑制剂。

    More
  • DR 2313 EI1037

    DR 2313是PARP-1,PARP-2 抑制剂。

    More
  • BYK 49187 EI0657

    BYK 49187是PARP-1,PARP-2 抑制剂。

    More
  • 4-HQN EI0280

    4-HQN是PARP 抑制剂。

    More
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