HSP
HSP (Heat shock proteins) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light, and during wound healing or tissue remodeling. Many members of this group perform chaperone function by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans.
Heat-shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins on the order of 60, 70, and 90 kilodaltons in size, respectively. The small 8-kilodalton protein ubiquitin, which marks proteins for degradation, also has features of a heat shock protein.
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Herbimycin A是Src 家族激酶抑制剂。也是Hsp90 抑制剂。
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Gedunin是Hsp90 抑制剂， 展现抗肿瘤抗疟活性。。
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EC 144是高亲和性，活性的选择性 Hsp90 抑制剂。
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CCT 018159是Hsp90 抑制剂。
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TRC 051384是TRC 051384 is an inducer of heat shock protein Hsp70。
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Herbimycin A是Src 家族激酶抑制剂。也是Hsp90 抑制剂。
More
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Gedunin是Hsp90 抑制剂， 展现抗肿瘤抗疟活性。。
More
-
EC 144是高亲和性，活性的选择性 Hsp90 抑制剂。
More
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CCT 018159是Hsp90 抑制剂。
More
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TRC 051384是TRC 051384 is an inducer of heat shock protein Hsp70。
More
