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Urotensin-II Receptor

The Urotensin-II Receptor (GPR14) is a class A rhodopsin family G protein coupled-receptor (GPCR) that is 386 amino acids long which binds primarily to the neuropeptide urotensin II.[1] The receptor quickly rose to prominence when it was found that when activated by urotensin II it induced the most potent vasoconstriction effect ever seen. While the precise function of the urotensin II receptor is not fully known is has been linked to cardiovascular effects, stress, and REM sleep.