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Metabolism


Metabolism is the set of life-sustaining chemical transformations within the cells of living organisms. The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. 

  • C188-9 EY8040

    C188-9 (TTI 101) is an effective STAT3 inhibitor that binds to STAT3 with high affinity, with a dissociation constant (Kd) of 4.7±0.4 nM. C188-9 is well tolerated in mice and exhibits good oral bioavailability, mainly accumulating in tumor tissues.

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  • SD-36 EY8039

    SD-36 是一种强效、选择性和有效的 PROTAC 降解剂，可降解 STAT3 蛋白，Kd 约为 50 nM。它还能有效降解细胞中突变的 STAT3 蛋白并抑制 STAT3 的转录活性，IC50 为 10 nM。它还具有抗肿瘤活性。

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  • AS1810722 EY8038

    一种口服有效的STAT6抑制剂，IC50为1.9nM。AS1810722显示出良好的CYP3A4抑制作用,一种稠合双环嘧啶衍生物，具有用于过敏性疾病，例如哮喘和特应性疾病研究的潜力。

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  • L-(+)-Ergothioneine EY6051

    Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity

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  • Pimavanserin EY2762

    Pimavanserin is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.

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