IAP


The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6.
  • UC 112 EI2847

    UC 112是IAP,XIAP 抑制剂, 具有抗肿瘤活性。。

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  • GDC-0152 EY1583

    GDC-0152是凋亡抑制蛋白IAPs高效抑制剂,结合XIAP BIR3结构域、ML-IAP BIR结构域、cIAP1 BIR3结构域和cIAP2 BIR3结构域的Ki值分别为28、14、17和43nM。

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  • Embelin EY1208

    Embelin,从矮地茶中分离的一种醌类化合物,是一种细胞凋亡的X染色体抑止剂(XIAP)的抑制剂,无细胞试验中IC50为4.1 μM。

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  • BV-6 EY0875

    BV-6是一种SMAC模拟的cIAP和XIAP的双重抑制剂。

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  • YM155 EY0758

    YM155 (Sepantronium Bromide)是一种有效的survivin抑制剂,通过抑制Survivin启动子活性而发挥作用,IC50为0.54 nM;对SV40启动子活性抑制作用不显著,对Survivin与XIAP相互作用抑制效果微弱。Phase 1/2。

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