PARP
PARP (Poly (ADP-ribose) polymerase) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. The PARP family comprises 17 members. They have all very different structures and functions in the cell. PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2) have a confirmed PARP activity. Others include PARP3, PARP6, TIPARP (or "PARP7"), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. PARP is found in the cell’s nucleus. The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair. PARP activation is an immediate cellular response to metabolic, chemical, or radiation-induced DNA SSB damage.
-
Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
More
-
EB 47是活性的 PARP-1 抑制剂。
More
-
DR 2313是PARP-1，PARP-2 抑制剂。
More
-
BYK 49187是PARP-1，PARP-2 抑制剂。
More
-
4-HQN是PARP 抑制剂。
More
-
Coumarin is a secondary phytochemical with hepatotoxic and carcinogenic properties.
More
-
EB 47是活性的 PARP-1 抑制剂。
More
-
DR 2313是PARP-1，PARP-2 抑制剂。
More
-
BYK 49187是PARP-1，PARP-2 抑制剂。
More
-
4-HQN是PARP 抑制剂。
More
