Home > Signal Pathway > Metabolism > DGAT

DGAT


DGAT (Diglyceride acyltransferase) catalyzes the formation of triglycerides from diacylglycerol and Acyl-CoA. The reaction catalyzed by DGAT is considered the terminal and only committed step in triglyceride synthesis and to be essential for the formation of adipose tissue.There are two isozymes of DGAT encoded by the genes DGAT1 and DGAT2. Although both isozymes catalyze similar reactions, they have no sequence homology to each other. DGAT-1 inhibitors have potential for the treatment of obesity and a number of DGAT-1 inhibitors are in clinical trials for this indication.

  • AZD 3988 EI0518

    AZD 3988是活性的，选择性 DGAT-1 抑制剂。

    More
    • Current page1, Total Pages1, Total Record1 First Prev 1 Next Last Goto
More