Sirtuin
Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaea and eukaryotes.
Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.
The dependence of sirtuins on NAD links their enzymatic activity directly to the energy status of the cell via the cellular NAD:NADH ratio, the absolute levels of NAD, NADH or nicotinamide or a combination of these variables.
-
SRT1720是一种选择性的SIRT1激活剂(EC1.5 = 0.16 μM)，比作用于SIRT2和SIRT3效果强230倍以上(EC1.5 = 37 μM, EC1.5 > 300 μM)。
More
-
AGK2是一个有效的选择性SIRT2抑制剂，IC50值为3.5 μM。
More
-
Resveratrol是天然产生的一种植物抗毒素，具有抗癌，抗炎，降血糖和其他有益心血管的作用。
More
-
Sirtinol是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。
More
-
Tenovin-1是SIRT1和SIRT2抑制剂，及p21和p53活化剂。
More
-
SRT1720是一种选择性的SIRT1激活剂(EC1.5 = 0.16 μM)，比作用于SIRT2和SIRT3效果强230倍以上(EC1.5 = 37 μM, EC1.5 > 300 μM)。
More
-
AGK2是一个有效的选择性SIRT2抑制剂，IC50值为3.5 μM。
More
-
Resveratrol是天然产生的一种植物抗毒素，具有抗癌，抗炎，降血糖和其他有益心血管的作用。
More
-
Sirtinol是一种特异性SIRT1和SIRT2抑制剂，IC50分别为131 μM和38 μM。
More
-
Tenovin-1是SIRT1和SIRT2抑制剂，及p21和p53活化剂。
More
