c-Kit (SCFR, tyrosine-protein kinase Kit,CD117)  is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. c-Kit is a receptor tyrosine kinase type III, which binds to stem cell factor. When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. Signalling through c-Kit plays a role in cell survival, proliferation, and differentiation.
  • APcK 110 EI0462

    APcK 110是KIT 抑制剂。

  • Sunitinib Malate EY0865

    Sunitinib Malate是一种多靶点受体酪氨酸激酶(RTK)抑制剂,作用于VEGFR1, VEGFR2, VEGFR3, PDGFRβ, FLT3,和CSF-1R时,IC50分别为15 nM, 38 nM, 30 nM, 55 nM, 21 nM,和35 nM。

  • Imatinib Mesylate EY0363

    Imatinib Mesylate (STI571)是Imatinib的甲磺酸盐,具有较好的口服生物利用度,是一种多靶点的抑制剂,同时作用于v-Abl, c-Kit和PDGFR,IC50分别为0.6 μM, 0.1 μM 和0.1 μM。

  • Imatinib EY0537

    Imatinib (STI571)是一种多靶点酪氨酸激酶抑制剂,作用于v- v-Abl, c-Kit和PDGFR 时,IC50分别为0.6, 0.1和0.1 μM。

  • Dasatinib Monohydrate EY0800

    Dasatinib是一种Src/Abl抑制剂,IC50分别为0.6 nM和0.8 nM。

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