c-RET


c-RET (RET proto-oncogene) encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules. RET gene results in the production of 3 different isoforms of the protein RET. RET51, RET43 and RET9 contain 51, 43 and 9 amino acids in their C-terminal tail respectively.[7] The biological roles of isoforms RET51 and RET9 are the most well studied in-vivo as these are the most common isoforms in which RET occurs.
  • Regorafenib EY1782

    Regorafenib (瑞格非尼; BAY 73-4506) 是多靶点抑制剂,对VEGFR1,VEGFR2,VEGFR3,PDGFRβ,Kit,RET和Raf-1的IC50分别为13 nM,4.2 nM,46 nM,22 nM,7 nM,1.5 nM和2.5 nM。

    More
  • Regorafenib EY1782

    Regorafenib (瑞格非尼; BAY 73-4506) 是多靶点抑制剂,对VEGFR1,VEGFR2,VEGFR3,PDGFRβ,Kit,RET和Raf-1的IC50分别为13 nM,4.2 nM,46 nM,22 nM,7 nM,1.5 nM和2.5 nM。

    More
  • Current page1, Total Pages1, Total Record1 First Prev 1 Next Last Goto