Src
There are 9 members part of the Src family kinases: c-Src , Yes, Fyn, Fgr, Yrk, Lyn, Blk, Hck, and Lck.[8] The expression of these Src family members are not the same throughout all tissues and cell types. Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. When src is activated, it promotes survival, angiogenesis, proliferation and invasion pathways. It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion,[16][17] and regulates matrix metalloproteinase-9 activity after intracerebral hemorrhage.
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Herbimycin A是Src 家族激酶抑制剂。也是Hsp90 抑制剂。
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AZM 475271是Src tyrosine 激酶抑制剂。
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A 419259 trihydrochloride是 Src家族激酶抑制剂。
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MCB-613 是一种有效的类固醇受体共激活因子(SRC) 刺激物。
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Src I1是作用于ATP binding和peptide binding双位点的Src激酶抑制剂。
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