P-gp
P-gp (permeability glycoprotein) is an important protein of the cell membrane that pumps many foreign substances out of cells. It is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi and bacteria and likely evolved as a defense mechanism against harmful substances. P-gp is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.
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Elacridar hydrochloride是P-gp 抑制剂。
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CP 100356 hydrochloride是P-gp 抑制剂。
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Reversan是选择性 MRP1,P-gp 抑制剂。
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PSC 833是P-gp-mediated MDR的抑制剂。
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Tariquidar (XR9576)是非竞争性P-gp抑制剂,Kd为5.1 nM,可逆转药物抗性在MDR细胞中。
More
-
Elacridar hydrochloride是P-gp 抑制剂。
More
-
CP 100356 hydrochloride是P-gp 抑制剂。
More
-
Reversan是选择性 MRP1,P-gp 抑制剂。
More
-
PSC 833是P-gp-mediated MDR的抑制剂。
More
-
Tariquidar (XR9576)是非竞争性P-gp抑制剂,Kd为5.1 nM,可逆转药物抗性在MDR细胞中。
More