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Microbiology


Microbiology  is the study of microscopic organisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, mycology, parasitology, and bacteriology.

Cellular microbiology attempts to use pathogenic microbes as tools for cell-biology research, and to employ cell-biology methods to understand the pathogenicity of microbes. Toxins and virulence factors from microbes have been used for decades to influence processes in eukaryotic cells and to study them. It has increasingly appeared that applying a purified toxin on a cell does not always provide the complete picture, and that understanding the role of the toxin in pathogenicity, the way the toxin promotes the microbe, the way the toxin is produced and the co-evolution of the toxin and its host-cell counterparts, is crucial.

  • LGK-974 EY0982

    LGK-974是特异的PORCN抑制剂,能抑制Wnt信号通路,IC50为0.4 nM。

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  • Fluorouracil EY0464

    Fluorouracil (5-Fluoracil, 5-FU)是DNA/RNA合成抑制剂,通过抑制胸苷酸合成酶(TS)而干扰核苷酸合成。

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  • IWR-1-endo EY0429

    IWR-1-endo, an active endo form of IWR-1, is a small molecule inhibitor for Wnt/β-catenin signaling via the inhibition of tankyrase. IWR-1-endo是一种Wnt通路抑制剂,IC50为180 nM,诱导Axin2蛋白水平,且促进β-catenin磷酸化。

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  • FH535 EY0435

    FH535, a dual small-molecule inhibitor of Wnt/β-catenin signaling pathway and the peroxisome proliferator-activated receptor (PPAR), shows potent inhibition of various cancers. FH535能双重抑制Wnt/beta-catenin和PPAR信号通路。

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  • Kartogenin EY0396

    Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. Kartogenin是针对软骨形成的小分子激动剂,促进软骨细胞分化(EC50为100nM),结合filamin A,并阻止其与转录因子CBFβ)的相互作用。

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