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Microbiology


Microbiology  is the study of microscopic organisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, mycology, parasitology, and bacteriology.

Cellular microbiology attempts to use pathogenic microbes as tools for cell-biology research, and to employ cell-biology methods to understand the pathogenicity of microbes. Toxins and virulence factors from microbes have been used for decades to influence processes in eukaryotic cells and to study them. It has increasingly appeared that applying a purified toxin on a cell does not always provide the complete picture, and that understanding the role of the toxin in pathogenicity, the way the toxin promotes the microbe, the way the toxin is produced and the co-evolution of the toxin and its host-cell counterparts, is crucial.

  • Pemetrexed EY1421

    Pemetrexed是一种新型抗叶酸抗代谢药物,作用于TS, DHFR和GARFT时,Ki分别为1.3 nM,7.2 nM,和65 nM。

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  • H 89 2HCl EY1400

    H 89 2HCl是一种有效的PKA抑制剂,Ki为48 nM,作用于PKA比作用于PKG选择性高10倍,比作用于PKC, MLCK,钙调蛋白激酶II和酪蛋白激I/II选择性高500倍。

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  • Istradefylline EY1344

    Istradefylline(KW-6002)是一种腺苷A2A受体(A2AR)选择性拮抗剂,Ki为2.2 nM。

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  • Wnt-C59 EY1294

    Wnt-C59 (C59)是一种PORCN抑制剂,作用于Wnt3A-调节的多聚TCF结合位点驱动的荧光素酶的激活,IC50为74 pM。

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  • KY02111 EY1087

    KY02111抑制Wnt信号,促进hPSCs分化为心肌细胞,可能对APC和GSK3β的下游起作用。

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