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Pemetrexed

培美曲塞二钠,LY-231514,Pemetrexed disodium

Pemetrexed是一种新型抗叶酸抗代谢药物，作用于TS， DHFR和GARFT时，Ki分别为1.3 nM，7.2 nM，和65 nM。

目录号
EY1421
EY1421
EY1421
EY1421
纯度
99.28%
99.28%
99.28%
99.28%
规格
1 mg
5 mg
50 mg
100 mg
原价
120
300
600
1050
售价
120
300
600
1050
库存
现货
现货
现货
现货
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订购
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  • 生物活性

    Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

  • 体外研究

  • 体内研究

    Saline

  • 激酶实验

  • 细胞实验

    0-30 μM

  • 动物实验

    100 mg/kg或150 mg/kg 腹腔注射

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Shih C, et al. Cancer Res. 1997, 57(6), 1116-1123.
    [2] McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998)
    [3] Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000)
    [4] John, W., et al.: Cancer, 88, 1807 (2000)

    分子式
    C20H21N5O6.5/2H2O.2Na    		 分子量
    516.42    		 CAS号
    150399-23-8    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    100 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00230542 Ovarian Cancer|Peritoneal Cancer|Fallopian Tube Cancer Drug: Carboplatin|Drug: Pemetrexed Dana-Farber Cancer Institute|Massachusetts General Hospital|Brigham and Women's Hospital Phase 2 2005-09-01 2017-03-22
    NCT02868892 Adenocarcinoma of the Cervix|Adenosquamous Cell Carcinoma of the Cervix Drug: Pemetrexed Western Regional Medical Center Phase 2 2015-07-01 2016-08-11
    NCT00712062 Primary Central Nervous System Lymphoma Drug: Pemetrexed University of Florida Phase 2 2009-02-01 2011-09-16
    NCT01333696 Squamous Cell Carcinoma of Head and Neck Drug: Pemetrexed Fudan University Phase 2 2011-04-01 2013-03-02
    NCT01918761 Non Small Cell Lung Cancer Drug: Dacomitinib, Pemetrexed Central European Cooperative Oncology Group Phase 1 2013-08-01 2016-02-17
    NCT00293579 Head and Neck Cancer Drug: Pemetrexed Ohio State University Comprehensive Cancer Center Phase 2 2006-02-01 2016-02-11
    NCT02004184 Carcinoma, Non-small-cell Lung Drug: maintenance pemetrexed|Drug: pemetrexed at progression Norwegian University of Science and Technology|St. Olavs Hospital Phase 3 2013-12-01 2016-12-12
    NCT00265785 Lung Cancer Drug: pemetrexed Southwest Oncology Group|National Cancer Institute (NCI) Phase 2 2006-07-01 2012-10-03
    NCT02588781 Colorectal Cancer Drug: Pemetrexed Samsung Medical Center Phase 2 2015-10-01 2015-10-27
    NCT02284490 Brain Metastases Drug: pemetrexed Rongjie Tao|National Natural Science Foundation of China|Shandong Cancer Hospital and Institute Phase 2 2014-11-01 2014-11-03
    NCT00216216 Small Cell Lung Cancer Drug: Pemetrexed Hoosier Cancer Research Network|Eli Lilly and Company|Walther Cancer Institute Phase 2 2005-01-01 2011-04-28
    NCT00700336 Malignant Pleural Mesothelioma|Solid Tumors Drug: pemetrexed, cisplatin and CBP501|Drug: pemetrexed and cisplatin CanBas Co. Ltd. Phase 1|Phase 2 2008-05-01 2012-12-19
    NCT00907179 Non-Small Cell Lung Cancer Drug: LBH 589|Drug: Pemetrexed University of Pittsburgh|Novartis Pharmaceuticals Phase 1 2009-07-01 2015-07-20
    NCT00528281 Advanced Non-Small Cell Lung Cancer|Lung Cancer, Non-Small Cell Drug: Lapatinib|Drug: Pemetrexed GlaxoSmithKline Phase 1 2007-09-01 2012-05-31
    NCT00487669 Advanced Non-small Cell Lung Cancer Drug: paclitaxel poliglumex, pemetrexed Dartmouth-Hitchcock Medical Center|CTI BioPharma Phase 2 2006-10-01 2013-11-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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