Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones.
The endocrine system consists of several glands, all in different parts of the body, that secrete hormones directly into the blood rather than into a duct system. Hormones have many different functions and modes of action; one hormone may have several effects on different target organs, and, conversely, one target organ may be affected by more than one hormone.
LGK-974是特异的PORCN抑制剂,能抑制Wnt信号通路,IC50为0.4 nM。
MoreNutlin-3a是Nutlin-3的活性对映体,抑制p53/MDM2相互作用,IC50为90 nM。
MoreIWR-1-endo, an active endo form of IWR-1, is a small molecule inhibitor for Wnt/β-catenin signaling via the inhibition of tankyrase. IWR-1-endo是一种Wnt通路抑制剂,IC50为180 nM,诱导Axin2蛋白水平,且促进β-catenin磷酸化。
MoreFH535, a dual small-molecule inhibitor of Wnt/β-catenin signaling pathway and the peroxisome proliferator-activated receptor (PPAR), shows potent inhibition of various cancers. FH535能双重抑制Wnt/beta-catenin和PPAR信号通路。
MoreKartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. Kartogenin是针对软骨形成的小分子激动剂,促进软骨细胞分化(EC50为100nM),结合filamin A,并阻止其与转录因子CBFβ)的相互作用。
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