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Dimethyl Fumarate

富马酸二甲酯

Dimethyl fumarate是Nrf2通路活化剂。

目录号
EY1236
EY1236
纯度
99.13%
99.13%
规格
100 mg
500 mg
原价
120
420
售价
120
420
库存
现货
现货
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  • 生物活性

    Dimethyl fumarate (DMF)is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Albrecht P, et al. J Neuroinflammation,?012, 9, 163.
    [2] Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678.
    [3] Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274.

    分子式
    C6H8O4    		 分子量
    144.13    		 CAS号
    624-49-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    29 mg/mL     		Water
    1.5 mg/mL    		 Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02461069 Multiple Sclerosis, Relapsing-Remitting Drug: Dimethyl fumarate University Hospital Muenster|Biogen Phase 4 2015-05-01 2015-12-08
    NCT02047097 Multiple Sclerosis Drug: dimethyl fumarate Biogen 2013-11-01 2017-01-27
    NCT02675413 Multiple Sclerosis|Multiple Sclerosis, Relapsing-Remitting Drug: Dimethyl Fumarate Washington University School of Medicine|Biogen Phase 4 2016-04-01 2016-07-19
    NCT02438137 Obstructive Sleep Apnea|OSA|Sleep Apnea Drug: Dimethyl fumarate|Drug: Placebo University of Michigan 2015-05-01 2016-12-27
    NCT02125604 Relapsing-Remitting Multiple Sclerosis Drug: dimethyl fumarate Biogen Phase 4 2014-06-01 2016-04-09
    NCT02969304 Multiple Sclerosis Drug: dimethyl fumarate Biogen 2016-12-01 2017-03-08
    NCT02784834 Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma Drug: dimethyl fumarate Michael Choi|The Leukemia and Lymphoma Society|University of California, San Diego Phase 1 2016-06-01 2017-03-13
    NCT02686684 Multiple Sclerosis, Dimethyl Fumarate, Diffusion Tensor Imaging Magnetic Resonance Imaging Drug: Dimethyl fumarate University at Buffalo 2015-11-01 2016-10-24
    NCT02981082 Systemic Sclerosis|Pulmonary; Hypertension Drug: Dimethyl Fumarate (DMF)|Drug: Placebo Oral Tablet University of Pittsburgh|Biogen Phase 1 2016-12-01 2016-12-13
    NCT02959658 Primary Progressive Multiple Sclerosis Drug: Dimethyl Fumarate|Drug: Placebo Oral Capsule Rigshospitalet, Denmark|Biogen Phase 2 2016-11-01 2016-12-02
    NCT02579681 Multiple Sclerosis, Relapsing-Remitting Drug: dimethyl fumarate Biogen Phase 3 2014-04-01 2017-02-02
    NCT02323269 Multiple Sclerosis, Relapsing-Remitting|Relapsing-Remitting Multiple Sclerosis Drug: dimethyl fumarate Biogen 2015-05-01 2016-04-07
    NCT01156311 Relapsing-Remitting Multiple Sclerosis|Multiple Sclerosis Drug: dimethyl fumarate Biogen Phase 2 2010-06-01 2017-02-14
    NCT01924832 Healthy Drug: dimethyl fumarate Biogen Phase 1 2013-08-01 2015-02-12
    NCT02090348 Relapsing-Remitting Multiple Sclerosis|Multiple Sclerosis Drug: dimethyl fumarate Biogen Phase 4 2015-06-01 2015-09-03
    NCT02472938 Relapsing Remitting Multiple Sclerosis Drug: dimethyl fumarate|Other: Placebo Biogen|GB Pharma Services & Consulting S.r.l. Unipersonale Phase 4 2015-07-01 2015-12-23
    NCT01930708 Relapsing-Remitting Multiple Sclerosis|Multiple Sclerosis Drug: dimethyl fumarate Biogen Phase 4 2013-10-01 2017-03-08
    NCT02736279 Multiple Sclerosis Drug: Dimethyl fumarate Virginia Simnad|Biogen|EvergreenHealth 2015-05-01 2016-11-03
    NCT02525874 Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis Drug: dimethyl fumarate Biogen Phase 3 2015-08-01 2017-02-09
    NCT01838668 Relapsing-Remitting Multiple Sclerosis|Multiple Sclerosis Drug: Placebo|Drug: dimethyl fumarate Biogen Phase 3 2013-03-01 2017-03-22

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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