NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.
Salmeterol xinafoatexinafoate是长效β2肾上腺素受体激动剂,可作用于哮喘和慢性阻塞性肺病。
MoreMedetomidine hydrochloride是α2肾上腺素受体激动剂,对α2和α1肾上腺素受体的Ki分别为1.08 nM和1750 nM。
MoreEpinephrine hydrochloride is a hormone and a neurotransmitter.
MoreDexmedetomidine是特护病房和麻醉师使用的一种镇静剂。
MoreMirtazapine是抗抑郁的5-HT受体抑制剂。
MoreSalmeterol xinafoatexinafoate是长效β2肾上腺素受体激动剂,可作用于哮喘和慢性阻塞性肺病。
MoreMedetomidine hydrochloride是α2肾上腺素受体激动剂,对α2和α1肾上腺素受体的Ki分别为1.08 nM和1750 nM。
MoreEpinephrine hydrochloride is a hormone and a neurotransmitter.
MoreDexmedetomidine是特护病房和麻醉师使用的一种镇静剂。
MoreMirtazapine是抗抑郁的5-HT受体抑制剂。
More