Dexmedetomidine是特护病房和麻醉师使用的一种镇静剂。
Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Virtanen R, et al. Eur J Pharmacol, 1988, 150(1-2), 9-14.
分子式 C13H16N2 |
分子量 200.28 |
CAS号 113775-47-6 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water 50 mg/mL |
Ethanol 50 mg/mL |
体内溶解度
NCT01498380 | Hemodynamic Instability | Drug: Dexmedetomidine | University of British Columbia | 2012-01-01 | 2014-02-05 | |
NCT02327156 | Vitreoretinal Surgery Under Sub-Tenon's Anesthesia | Drug: dexmedetomidine | Magrabi Eye & Ear Hospital | Phase 3 | 2014-01-01 | 2014-12-29 |
NCT02566863 | Haemodynamic Effects of Dexmedetomidine | Drug: Dexmedetomidine | Medical University of Gdansk | Phase 4 | 2015-06-01 | 2017-03-21 |
NCT02187068 | Obesity | Drug: Dexmedetomidine | Pontificia Universidad Catolica de Chile | Phase 4 | 2012-04-01 | 2014-07-07 |
NCT02715154 | Cesarean Section, Affecting Fetus or Newborn | Drug: Dexmedetomidine|Drug: Placebo | The First Affiliated Hospital with Nanjing Medical University | Phase 1 | 2015-06-01 | 2016-03-21 |
NCT02108171 | Benign Neoplasm of Vocal Fold - Glottis | Drug: Dexmedetomidine|Drug: placebo | Guangzhou First Municipal People鈥檚 Hospital | 2014-03-01 | 2016-02-13 | |
NCT01485380 | Dexmedetomidine Induced Sedation | Drug: dexmedetomidine | Massachusetts General Hospital | 2012-09-01 | 2016-06-20 | |
NCT01900405 | Traumatic Brain Injury|Children | Drug: Dexmedetomidine | University of Sao Paulo|Boston Children鈥檚 Hospital | 2013-04-01 | 2013-07-11 | |
NCT02557867 | Obesity | Drug: Dexmedetomidine | Pontificia Universidad Catolica de Chile | Phase 4 | 2015-08-01 | 2016-10-10 |
NCT02529202 | Hypoxic-ischemic Encephalopathy | Drug: Dexmedetomidine | Seattle Children's Hospital | Early Phase 1 | 2016-03-01 | 2017-01-10 |
NCT01976754 | Sepsis|Agitation | Drug: Dexmedetomidine | First Affiliated Hospital of Zhejiang University | 2013-09-01 | 2013-10-30 | |
NCT01864187 | Obesity | Drug: Dexmedetomidine | Guangzhou General Hospital of Guangzhou Military Command | Phase 4 | 2013-06-01 | 2015-03-11 |
NCT00345384 | Post-operative Pain|Respiratory Depression | Drug: Dexmedetomidine|Other: Placebo (Normal Saline) | Baylor Research Institute | Phase 1|Phase 2 | 2008-05-01 | 2016-01-12 |
NCT02155010 | Blood Pressure|Anxiety | Drug: Dexmedetomidine|Drug: Dexmedetomidine with heavy bupivacaine | Inje University | 2014-03-01 | 2016-08-03 | |
NCT00573066 | Hypoplastic Left Heart|Tetralogy of Fallot|Tricuspid Atresia | Drug: Dexmedetomidine | Athena Zuppa|Children's Hospital of Philadelphia | Phase 1 | 2004-05-01 | 2013-02-28 |
NCT01116700 | Seizure Disorders | Drug: Dexmedetomidine | University of California, San Francisco | Phase 1 | 2010-12-01 | 2013-08-06 |
NCT02299232 | Anesthesia | Drug: Dexmedetomidine | Sisli Etfal Training & Research Hospital | Phase 4 | 2014-02-01 | 2014-11-19 |
NCT01920542 | Acute Renal Injury | Drug: Dexmedetomidine|Drug: no dexmedetomidine | Gachon University Gil Medical Center | 2013-09-01 | 2016-11-08 | |
NCT00837187 | Sedation | Drug: Intravenous dexmedetomidine|Drug: Intranasal dexmedetomidine | University of Turku | Phase 1 | 2009-03-01 | 2010-01-12 |
NCT02459509 | Anxiety, Separation | Drug: Dexmedetomidine | The University of Hong Kong | Phase 4 | 2015-06-01 | 2016-04-15 |
NCT00576381 | Tetrology of Fallot|Heart Ventricle|Hypoplastic Left Heart | Drug: Dexmedetomidine | Athena Zuppa|Children's Hospital of Philadelphia | Phase 1 | 2006-04-01 | 2013-04-10 |
NCT01887184 | Gastrointestinal Disease | Drug: Dexmedetomidine | The University of Hong Kong | Phase 3 | 2009-01-01 | 2014-10-24 |
NCT02757495 | Delayed Emergence From Anesthesia | Drug: Dexmedetomidine | Suez Canal University | Phase 4 | 2016-04-01 | 2016-05-03 |
NCT02004613 | Heart Disease | Drug: Dexmedetomidine|Drug: Placebo | The Cleveland Clinic|Hospira, Inc. | Phase 4 | 2013-06-01 | 2017-02-03 |
NCT00455143 | Postoperative Delirium|PD|Postoperative Cognitive Dysfunction|POCD | Drug: Precedex (Dexmedetomidine) | Icahn School of Medicine at Mount Sinai | Phase 4 | 2006-09-01 | 2016-03-16 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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