Home > 暂无记录 Signal Pathway > NF-κB

NF-κB


NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.

  • L-748，337 EI1493

    L-748，337是选择性 β3 拮抗剂。

    More

  • JP 1302 dihydrochloride EI1403

    JP 1302 dihydrochloride是活性选择性 α2C 拮抗剂。

    More

  • Imiloxan hydrochloride EI1342

    Imiloxan hydrochloride是高选择性α2B拮抗剂。

    More

  • Atovaquone EY0668

    Atovaquone用于治疗或预防肺孢子菌肺炎，弓形虫病，疟疾和巴贝西虫。

    More

  • Vemurafenib EY1636

    Vemurafenib (PLX4032, RG7204)是一种新型有效的B-RafV600E抑制剂，IC50为31 nM。

    More

  • L-748，337 EI1493

    L-748，337是选择性 β3 拮抗剂。

    More

  • JP 1302 dihydrochloride EI1403

    JP 1302 dihydrochloride是活性选择性 α2C 拮抗剂。

    More

  • Imiloxan hydrochloride EI1342

    Imiloxan hydrochloride是高选择性α2B拮抗剂。

    More

  • Atovaquone EY0668

    Atovaquone用于治疗或预防肺孢子菌肺炎，弓形虫病，疟疾和巴贝西虫。

    More

  • Vemurafenib EY1636

    Vemurafenib (PLX4032, RG7204)是一种新型有效的B-RafV600E抑制剂，IC50为31 nM。

    More
    • Current page20, Total Pages28, Total Record140 First Prev 1819202122 Next Last Goto
More