Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience is recognized as a branch of biology.
A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the brain and spinal cord of the central nervous system (CNS), and of the ganglia of the peripheral nervous system (PNS).
All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated, which travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives.
Sodium Butyrate (丁酸钠) 被报道证实为HDAC抑制剂,从而导致组蛋白过乙酰化。
MoreDAPT (GSI-IX)是新型γ-分泌酶抑制剂,抑制HEK 293细胞中全部Aβ, IC50为20 nM。
MorePCI-34051是高活性的HDAC8特异性抑制剂,IC50为10 nM,比对其它HDAC亚型的抑制性高200倍以上。
MorePanobinostat (LBH589)是一种新型的,广谱的HDAC抑制剂,IC50为5 nM。
MoreRGFP966是一种HDAC抑制剂,作用于HDAC3的IC50为0.08μM ,比作用于其他HDAC选择性高200倍以上。
More