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Sodium butyrate

丁酸钠

Sodium Butyrate (丁酸钠) 被报道证实为HDAC抑制剂，从而导致组蛋白过乙酰化。

目录号
EY0878
EY0878
纯度
99.25%
99.25%
规格
1 g
5 g
原价
260
550
售价
260
550
库存
现货
现货
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  • 生物活性

    Sodium butyrate is the sodium salt of butyric acid and has long been known as an inhibitor of histone deacetylases (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). This compound has been shown to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Archer SY, et al. Proc Natl Acad Sci U S A, 1998, 95(12), 6791-6796.
    [2] Davie, James R., et al., 2003. Inhibition of histone deacetylase activity by butyrate. The Journal of nutrition. 133(7 Suppl): 2485S-2493S.
    [3] Joseph, Jeena., et al., 2004. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene. 23(37): 6304-15.
    [4] Sealy, L., et al., 1978. The effect of sodium butyrate on histone modification. Cell. 14(1): 115-21.
    [5] Sekhavat, Anoushe., et al., 2007. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochemistry and cell biology = Biochimie et biologie cellulaire. 85(6): 751-8.

    分子式
    C4H7NaO2    		 分子量
    110.09    		 CAS号
    156-54-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    20 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02654405 Schizophrenic Disorders|Cognitive Function Dietary Supplement: Sodium Butyrate|Other: Placebo Nathan Kline Institute for Psychiatric Research|Stanley Medical Research Institute Phase 2|Phase 3 2016-04-01 2016-08-11
    NCT03010865 Schizophrenic Disorder|Cognitive Impairment Drug: Sodium Butyrate|Drug: Placebo Oral Capsule Shanghai Mental Health Center|Stanley Medical Research Institute Phase 2|Phase 3 2017-02-01 2017-01-03
    NCT00800930 Shigellosis Biological: Sodium Butyrate|Biological: Saline International Centre for Diarrhoeal Disease Research, Bangladesh|Swedish International Development Cooperation Agency (SIDA)|Karolinska Institutet Phase 2 2005-01-01 2011-12-06
    NCT00693355 Healthy Other: Sodium butyrate|Other: NaCl Maastricht University Medical Center|Top Institute Food and Nutrition 2005-12-01 2017-02-22
    NCT00696098 Gut Health Other: sodium butyrate|Other: NaCl Maastricht University Medical Center|Top Institute Food and Nutrition 2007-05-01 2017-02-22
    NCT02271802 SCFA Metabolism Dietary Supplement: Sodium butyrate|Dietary Supplement: NaCl Maastricht University Medical Center|Top Institute Food and Nutrition 2009-06-01 2014-10-21
    NCT01757379 Short Chain Fatty Acids Bioavailability Dietary Supplement: 13C-labeled Acetate|Dietary Supplement: 13C-labeled propionate|Dietary Supplement: 13C-labeled butyrate|Dietary Supplement: Inulin Katholieke Universiteit Leuven 2011-04-01 2015-01-13
    NCT02090504 Alcohol Withdrawal Syndrome|Alcohol Dependence Drug: Sodium Oxybate (SMO)|Drug: Oxazepam Catholic University of the Sacred Heart|CT Pharmaceutical Industries, Sanremo - Italy|University of Bologna|Medical University of Vienna Phase 4 2002-02-01 2014-03-17
    NCT01983046 Obesity|Type 2 Diabetes Drug: Three different mixture of acetate, butyrate and propionate and palcebo Maastricht University Medical Center|Top Institute Food and Nutrition 2013-09-01 2014-10-20
    NCT01518348 Contact Dermatitis Biological: Patch Test Allerderm Phase 3 2012-12-01 2013-02-26
    NCT01797562 Allergic Contact Dermatitis Drug: T.R.U.E. Test Panel 3.2 Allerderm Phase 4 2012-12-01 2014-09-22
    NCT00672308 Cholera Other: Benefiber|Other: Benefiber with ORS|Other: Benefiber with ORS|Other: Benefiber with ORS|Other: the reduced-osmolarity WHO-ORS without added Benefiber|Other: the reduced-osmolarity WHO-ORS without added Benefiber International Centre for Diarrhoeal Disease Research, Bangladesh|University of Basel Phase 2 2003-05-01 2008-05-05
    NCT01862380 Adrenal Hyperplasia, Congenital|21-hydroxylase Deficiency Other: Functional explorations|Other: Functional explorations Assistance Publique - H么pitaux de Paris 2013-02-01 2016-09-28
    NCT00675272 Brain Death Drug: hydrocortisone|Drug: sodium chloride Kuopio University Hospital|Tampere University Hospital 2008-05-01 2015-04-03
    NCT00147004 Shock, Septic Drug: hydrocortisone sodium succinate|Drug: Placebo Hadassah Medical Organization|European Society of Intensive Care Medicine|International Sepsis Forum|The Gorham Foundation Phase 3 2002-03-01 2008-04-23
    NCT01608945 Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver Drug: Hydrocortisone sodium succinate Eastern Hepatobiliary Surgery Hospital 2008-04-01 2012-05-30
    NCT02549768 Pituitary Neoplasms Drug: Dexmedetomidine|Drug: Sodium Chloride 0.9% Pontificia Universidad Catolica de Chile Phase 4 2015-09-01 2016-10-10
    NCT02152553 Addison Disease Drug: Hydrocortisone|Drug: Placebo Vastra Gotaland Region 2014-05-01 2016-01-04
    NCT00529841 Adrenal Hyperplasia, Congenital Drug: Hydrocortisone sodium acetate Baylor College of Medicine 2007-01-01 2015-09-10
    NCT02602210 Liver Cirrhosis Drug: Hydrocortisone|Drug: NaCL 0.9% Universitaire Ziekenhuizen Leuven Phase 3 2015-01-01 2015-11-09
    NCT02691858 Intussusception Drug: Hydrocortisone|Drug: Saline Cairo University 2015-04-01 2017-02-05

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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